Loyal veteran Navy S.E.A.L. Lt. A.K. Waters (Bruce Willis) is sent into the heart of war-torn Africa on a hazardous assignment to rescue Dr. Lena Hendricks (Monica Bellucci), a U.S. citizen who runs a mission. When the beautiful doctor refuses to abandon the refugees in her care, Lt. Waters finds himself having to choose between following orders and the dictates of his own conscious.

Together, they begin a dangerous trek through the deadly jungle, all the while being pursued by a rebel militia group, with only one goal in mind: to assassinate Lt. Waters' unit and the refugees in his care.